Non-Linear Mixed-Effects modelling using Stochastic Differential Equations CRAN Task View: DifferentialEquations (http://CRAN.R-project.org/view=DifferentialEquations) This package provides functions for estimation of linear and non-linear mixed-effects models using stochastic differential equations. Moreover it provides functions for finding smoothed estimates of model states and for simulation. The package allows for any multivariate non-linear time-variant model to be specified, and it also handels multidimentional input, co-variates, missing observations and specification of dosage regimen. Software Depends: MASS, numDeriv, odesolve, ucminf Authors <psmpackage@imm.dtu.dk> Stig Bousgaard Mortensen <sbm@imm.dtu.dk> and Søren Klim <skl@imm.dtu.dk> GPL (>= 2) 2012-01-15 application/tgz http://CRAN.R-project.org/package=PSM