<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Evaluation of Failure Time Surrogate Endpoints in Individual
Patient Data Meta-Analyses</dc:title>
  <dc:title>R package surrosurv version 1.1.27</dc:title>
  <dc:description>Provides functions for the evaluation of
    surrogate endpoints when both the surrogate and the true endpoint are failure
    time variables. The approaches implemented are:
    (1) the two-step approach (Burzykowski et al, 2001) &lt;DOI:10.1111/1467-9876.00244&gt; with a copula model (Clayton, Plackett, Hougaard) at
    the first step and either a linear regression of log-hazard ratios at the second
    step (either adjusted or not for measurement error);
    (2) mixed proportional hazard models estimated via mixed Poisson GLM
    (Rotolo et al, 2017 &lt;DOI:10.1177/0962280217718582&gt;).</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: R (&gt;= 3.5.0)</dc:relation>
  <dc:relation>Imports: copula, eha, grDevices, lme4, MASS, Matrix, msm, mvmeta,
optimx, parallel, parfm, stats, survival</dc:relation>
  <dc:relation>Suggests: R.rsp, testthat (&gt;= 3.0.0)</dc:relation>
  <dc:creator>Dan Chaltiel &lt;dan.chaltiel@gustaveroussy.fr&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Federico Rotolo [aut] (ORCID: &lt;https://orcid.org/0000-0003-4837-6501&gt;),
  Xavier Paoletti [ctb],
  Marc Buyse [ctb],
  Tomasz Burzykowski [ctb],
  Stefan Michiels [ctb] (ORCID: &lt;https://orcid.org/0000-0002-6963-2968&gt;),
  Dan Chaltiel [cre] (ORCID: &lt;https://orcid.org/0000-0003-3488-779X&gt;)</dc:contributor>
  <dc:rights>GPL-2</dc:rights>
  <dc:date>2025-10-10</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=surrosurv</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.surrosurv</dc:identifier>
</oai_dc:dc>
