AGSDest: Estimation in Adaptive Group Sequential Trials

Calculation of repeated confidence intervals as well as confidence intervals based on the stage-wise ordering in group sequential designs and adaptive group sequential designs. For adaptive group sequential designs the confidence intervals are based on the conditional rejection probability principle. Currently the procedures do not support the use of futility boundaries or more than one adaptive interim analysis.

Version: 2.3
Imports: stats, graphics, grDevices, ldbounds
Published: 2015-07-02
Author: Niklas Hack, Werner Brannath, Matthias Brueckner
Maintainer: Matthias Brueckner <mwb at>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: yes
In views: ClinicalTrials
CRAN checks: AGSDest results


Reference manual: AGSDest.pdf
Vignettes: AGSDest user guide
Package source: AGSDest_2.3.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
OS X Snow Leopard binaries: r-release: AGSDest_2.3.tgz, r-oldrel: AGSDest_2.2.tgz
OS X Mavericks binaries: r-release: AGSDest_2.3.tgz
Old sources: AGSDest archive