COMBIA: Synergy/Antagonism Analyses of Drug Combinations

A comprehensive synergy/antagonism analyses of drug combinations with quality graphics and data. The analyses can be performed by Bliss independence and Loewe additivity models. 'COMBIA' provides improved statistical analysis and makes only very weak assumption of data variability while calculating bootstrap intervals (BIs). It is based on heteroscedasticity controlled resampling (bootstrapping) and includes a global (omnibus) test. Finally, package saves analyzed data, 2D and 3D plots ready to use in research publications. 'COMBIA' does not require manual data entry. Data can be directly input from wetlab experimental platforms for example fluostar, automated robots etc. One only needs to call a single function, analyzeCOMBO(), to perform all analysis (examples are provided with sample data).

Version: 1.0.5
Depends: hash, lattice, latticeExtra, oro.nifti
Imports: gdata, grDevices, stats, utils
Published: 2017-10-23
Author: Muhammad Kashif
Maintainer: Muhammad Kashif <Muhammad.Kashif at>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: no
SystemRequirements: perl (>= 5.10.0)
Citation: COMBIA citation info
CRAN checks: COMBIA results


Reference manual: COMBIA.pdf
Package source: COMBIA_1.0.5.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
OS X El Capitan binaries: r-release: COMBIA_1.0.5.tgz
OS X Mavericks binaries: r-oldrel: COMBIA_1.0.5.tgz
Old sources: COMBIA archive


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