GMAC: Genomic Mediation Analysis with Adaptive Confounding Adjustment

Performs genomic mediation analysis with adaptive confounding adjustment (GMAC) proposed by Yang et al. (2017) <doi:10.1101/078683>. It implements large scale mediation analysis and adaptively selects potential confounding variables to adjust for each mediation test from a pool of candidate confounders. The package is tailored for but not limited to genomic mediation analysis (e.g., cis-gene mediating trans-gene regulation pattern where an eQTL, its cis-linking gene transcript, and its trans-gene transcript play the roles as treatment, mediator and the outcome, respectively), restricting to scenarios with the presence of cis-association (i.e., treatment-mediator association) and random eQTL (i.e., treatment).

Version: 1.0
Depends: parallel, qvalue
Published: 2017-04-09
Author: Fan Yang, Jiebiao Wang and Lin Chen
Maintainer: Fan Yang <yfcarolyn at>
License: GPL-2 | GPL-3 [expanded from: GPL]
NeedsCompilation: no
CRAN checks: GMAC results


Reference manual: GMAC.pdf
Package source: GMAC_1.0.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
OS X El Capitan binaries: r-release: not available
OS X Mavericks binaries: r-oldrel: GMAC_1.0.tgz


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