Mediana: Clinical Trial Simulations

Provides a general framework for clinical trial simulations based on the Clinical Scenario Evaluation (CSE) approach. The package supports a broad class of data models (including clinical trials with continuous, binary, survival-type and count-type endpoints as well as multivariate outcomes that are based on combinations of different endpoints), analysis strategies and commonly used evaluation criteria.

Version: 1.0.8
Imports: doParallel, doRNG, foreach, MASS, mvtnorm, stats, survival, utils
Suggests: flextable, knitr, officer, rmarkdown, pander
Published: 2019-05-08
DOI: 10.32614/CRAN.package.Mediana
Author: Gautier Paux, Alex Dmitrienko.
Maintainer: Gautier Paux <gautier at>
License: GPL-2
NeedsCompilation: no
Materials: README NEWS
In views: ClinicalTrials
CRAN checks: Mediana results


Reference manual: Mediana.pdf
Vignettes: Adjusted p-values and one-sided simultaneous confidence limits
Case studies
Mediana: an R package for clinical trial simulations


Package source: Mediana_1.0.8.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): Mediana_1.0.8.tgz, r-oldrel (arm64): Mediana_1.0.8.tgz, r-release (x86_64): Mediana_1.0.8.tgz, r-oldrel (x86_64): Mediana_1.0.8.tgz
Old sources: Mediana archive


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