MetaSubtract: Subtracting Summary Statistics of One or more Cohorts from Meta-GWAS Results

If results from a meta-GWAS are used for validation in one of the cohorts that was included in the meta-analysis, this will yield biased (i.e. too optimistic) results. The validation cohort needs to be independent from the meta-GWAS results. MetaSubtract will subtract the results of the respective cohort from the meta-GWAS results analytically without having to redo the meta-GWAS analysis using the leave-one-out methodology. It can handle different meta-analyses methods and takes into account if single or double genomic control correction was applied to the original meta-analysis. It can be used for whole GWAS, but also for a limited set of SNPs or other genetic markers.

Version: 1.2
Published: 2017-10-13
Author: Ilja M. Nolte
Maintainer: Ilja M. Nolte <i.m.nolte at>
License: GPL (≥ 3)
NeedsCompilation: no
CRAN checks: MetaSubtract results


Reference manual: MetaSubtract.pdf
Package source: MetaSubtract_1.2.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
OS X El Capitan binaries: r-release: MetaSubtract_1.2.tgz
OS X Mavericks binaries: r-oldrel: MetaSubtract_1.2.tgz
Old sources: MetaSubtract archive


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