MiRKAT: Microbiome Regression-Based Kernel Association Test

Test for overall association between microbiome composition data with a continuous or dichotomous outcome via phylogenetic kernels. The phenotype can be univariate continuous or binary phenotypes (Zhao et al. (2015) <doi:10.1016/j.ajhg.2015.04.003>), survival outcomes (Plantinga et al. (2017) <doi:10.1186/s40168-017-0239-9>), multivariate (Zhan et al. (2017) <doi:10.1002/gepi.22030>) and structured phenotypes (Zhan et al. (2017) <doi:10.1111/biom.12684>). For all these effect, the microbiome community effect was modeled nonparametrically through a kernel function, which can incorporate the phylogenetic tree information.

Version: 1.0.1
Depends: R (≥ 2.13.0), survival, PearsonDS, GUniFrac, MASS
Published: 2018-04-25
Author: Haotian Zheng [aut], Xiang Zhan [aut], Anna Plantinga [aut], Michael Wu [aut], Ni Zhao [aut, cre], Jun Chen [aut]
Maintainer: Ni Zhao <nzhao10 at jhu.edu>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: yes
Materials: README
CRAN checks: MiRKAT results

Downloads:

Reference manual: MiRKAT.pdf
Vignettes: MiRKAT
Package source: MiRKAT_1.0.1.tar.gz
Windows binaries: r-devel: MiRKAT_1.0.1.zip, r-release: MiRKAT_1.0.1.zip, r-oldrel: MiRKAT_1.0.1.zip
OS X binaries: r-release: MiRKAT_1.0.1.tgz, r-oldrel: MiRKAT_1.0.1.tgz
Old sources: MiRKAT archive

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