MiRSEA: 'MicroRNA' Set Enrichment Analysis

The tools for 'MicroRNA Set Enrichment Analysis' can identify risk pathways(or prior gene sets) regulated by microRNA set in the context of microRNA expression data. (1) This package constructs a correlation profile of microRNA and pathways by the hypergeometric statistic test. The gene sets of pathways derived from the three public databases (Kyoto Encyclopedia of Genes and Genomes ('KEGG'); 'Reactome'; 'Biocarta') and the target gene sets of microRNA are provided by four databases('TarBaseV6.0'; 'mir2Disease'; 'miRecords'; 'miRTarBase';). (2) This package can quantify the change of correlation between microRNA for each pathway(or prior gene set) based on a microRNA expression data with cases and controls. (3) This package uses the weighted Kolmogorov-Smirnov statistic to calculate an enrichment score (ES) of a microRNA set that co-regulate to a pathway , which reflects the degree to which a given pathway is associated with the specific phenotype. (4) This package can provide the visualization of the results.

Version: 1.1
Depends: R (≥ 2.15.1)
Suggests: stats, graphics, grDevices
Published: 2015-07-01
Author: Junwei Han, Siyao Liu
Maintainer: Junwei Han <hanjunwei1981 at 163.com>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: no
CRAN checks: MiRSEA results

Downloads:

Reference manual: MiRSEA.pdf
Vignettes: MiRSEA Overview
Package source: MiRSEA_1.1.tar.gz
Windows binaries: r-devel: MiRSEA_1.1.zip, r-release: MiRSEA_1.1.zip, r-oldrel: MiRSEA_1.1.zip
OS X El Capitan binaries: r-release: MiRSEA_1.1.tgz
OS X Mavericks binaries: r-oldrel: MiRSEA_1.1.tgz
Old sources: MiRSEA archive

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