NNTbiomarker: Calculate Design Parameters for Biomarker Validation Studies

Helps a clinical trial team discuss the clinical goals of a well-defined biomarker with a diagnostic, staging, prognostic, or predictive purpose. From this discussion will come a statistical plan for a (non-randomized) validation trial. Both prospective and retrospective trials are supported. In a specific focused discussion, investigators should determine the range of "discomfort" for the NNT, number needed to treat. The meaning of the discomfort range, [NNTlower, NNTupper], is that within this range most physicians would feel discomfort either in treating or withholding treatment. A pair of NNT values bracketing that range, NNTpos and NNTneg, become the targets of the study's design. If the trial can demonstrate that a positive biomarker test yields an NNT less than NNTlower, and that a negative biomarker test yields an NNT less than NNTlower, then the biomarker may be useful for patients. A highlight of the package is visualization of a "contra-Bayes" theorem, which produces criteria for retrospective case-controls studies.

Version: 0.29.11
Imports: shiny, xtable, stringr, magrittr, mvbutils
Suggests: testthat (≥ 0.8.1), knitr (≥ 1.6), rmarkdown, ggplot2, plyr
Published: 2015-08-21
Author: Roger Day
Maintainer: Roger Day <day01 at pitt.edu>
License: GPL-3
NeedsCompilation: no
CRAN checks: NNTbiomarker results

Downloads:

Reference manual: NNTbiomarker.pdf
Vignettes: The biomarker crisis
Using the NNTbiomarker package
The debugTools component
Package source: NNTbiomarker_0.29.11.tar.gz
Windows binaries: r-devel: NNTbiomarker_0.29.11.zip, r-release: NNTbiomarker_0.29.11.zip, r-oldrel: NNTbiomarker_0.29.11.zip
OS X El Capitan binaries: r-release: NNTbiomarker_0.29.11.tgz
OS X Mavericks binaries: r-oldrel: NNTbiomarker_0.29.11.tgz
Old sources: NNTbiomarker archive

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