The package can identify the dysregulated KEGG pathways based on global influence from the internal effect of pathways and crosstalk between pathways. (1) The PAGI package can prioritize the pathways associated with two biological states by statistical significance or FDR. (2) The PAGI package can evaluated the global influence factor (GIF) score in the global gene-gene network constructed based on the relationships of genes extracted from each pathway in KEGG database and the overlapped genes between pathways.
|Depends:||R (≥ 2.15.1), igraph|
|Author:||Junwei Han,Yanjun Xu,Haixiu Yang,Chunquan Li and Xia Li|
|Maintainer:||Junwei Han <hanjunwei1981 at 163.com>|
|License:||GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]|
|CRAN checks:||PAGI results|
|Windows binaries:||r-devel: PAGI_1.0.zip, r-release: PAGI_1.0.zip, r-oldrel: PAGI_1.0.zip|
|OS X El Capitan binaries:||r-release: PAGI_1.0.tgz|
|OS X Mavericks binaries:||r-oldrel: PAGI_1.0.tgz|
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