Power2Stage: Power and Sample-size Distribution of 2-stage Bioequivalence Studies

- Contains a function to calculate power and sample-size distribution of 2-stage bioequivalence (BE) studies with a 2x2 crossover design according to Potvin et al. / Montague et al. modified to include a futility Nmax and modified to do the sample size estimation step with PE and mse of stage 1. - Contains further a function with the modifications according to Karalis & Macheras which use PE and mse from stage 1 also for the power monitoring steps. - The third function power.2stage.fC() calculates power and sample size distribution of 2-stage BE studies with a futility criterion for the point estimator or CI of T/R from stage 1. - The fourth function power.2stage.GS() calculates power of non-adaptive group sequential (2-stage) BE studies. - The fifth function power.2stage.p() calculates power and sample size distribution of 2-stage BE studies with 2 parallel groups. - Another function power.2stage.ssr() allows the power calculation for 2-stage studies with (blinded) interim sample size re-estimation. All the functions use simulations to obtain their results.

Version: 0.2-2
Depends: PowerTOST
Published: 2014-12-08
Author: Detlew Labes [aut, cre], Helmut Schuetz [ctb]
Maintainer: Detlew Labes <DetlewLabes at gmx.de>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: no
Materials: NEWS
CRAN checks: Power2Stage results

Downloads:

Reference manual: Power2Stage.pdf
Package source: Power2Stage_0.2-2.tar.gz
Windows binaries: r-devel: Power2Stage_0.2-2.zip, r-release: Power2Stage_0.2-2.zip, r-oldrel: Power2Stage_0.2-2.zip
OS X Snow Leopard binaries: r-release: Power2Stage_0.2-2.tgz, r-oldrel: Power2Stage_0.2-2.tgz
OS X Mavericks binaries: r-release: Power2Stage_0.2-2.tgz
Old sources: Power2Stage archive