SampleSize4ClinicalTrials: Sample Size Calculation for Mean and Proportion Comparisons in Phase 3 Clinical Trials

The design of phase 3 clinical trials can be classified into 4 types: (1) Testing for equality;(2) Superiority trial;(3) Non-inferiority trial; and (4) Equivalence trial according to the goals. Given that none of the available packages combines these designs in a single package, this package has made it possible for researchers to calculate sample size when comparing means or proportions in phase 3 clinical trials with different designs. The ssc function can calculate the sample size with pre-specified type 1 error rate,statistical power and effect size according to the hypothesis testing framework. Furthermore, effect size is comprised of true treatment difference and non-inferiority or equivalence margins which can be set in ssc function. (Reference: Yin, G. (2012). Clinical Trial Design: Bayesian and Frequentist Adaptive Methods. John Wiley & Sons.)

Version: 0.1.0
Published: 2017-09-17
Author: Hongchao Qi
Maintainer: Hongchao Qi <qhcisahero1992 at sina.cn>
License: GPL-2
NeedsCompilation: no
CRAN checks: SampleSize4ClinicalTrials results

Downloads:

Reference manual: SampleSize4ClinicalTrials.pdf
Package source: SampleSize4ClinicalTrials_0.1.0.tar.gz
Windows binaries: r-devel: SampleSize4ClinicalTrials_0.1.0.zip, r-release: SampleSize4ClinicalTrials_0.1.0.zip, r-oldrel: SampleSize4ClinicalTrials_0.1.0.zip
OS X El Capitan binaries: r-release: SampleSize4ClinicalTrials_0.1.0.tgz
OS X Mavericks binaries: r-oldrel: SampleSize4ClinicalTrials_0.1.0.tgz

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