SimDissolution: Modeling and Assessing Similarity of Drug Dissolutions Profiles

Implementation of a model-based bootstrap approach for testing whether two formulations are similar. The package provides a function for fitting a pharmacokinetic model to time-concentration data and comparing the results for all five candidate models regarding the Residual Sum of Squares (RSS). The candidate set contains a First order, Hixson-Crowell, Higuchi, Weibull and a logistic model. The assessment of similarity implemented in this package is performed regarding the maximum deviation of the profiles. See Moellenhoff et al. (2018) <doi:10.1002/sim.7689> for details.

Version: 0.1.0
Depends: dplyr, alabama, mvtnorm, graphics
Published: 2019-09-27
DOI: 10.32614/CRAN.package.SimDissolution
Author: Kathrin Moellenhoff
Maintainer: Kathrin Moellenhoff <kathrin.moellenhoff at>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: no
CRAN checks: SimDissolution results


Reference manual: SimDissolution.pdf


Package source: SimDissolution_0.1.0.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): SimDissolution_0.1.0.tgz, r-oldrel (arm64): SimDissolution_0.1.0.tgz, r-release (x86_64): SimDissolution_0.1.0.tgz, r-oldrel (x86_64): SimDissolution_0.1.0.tgz


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