VNM: Using V-algorithm and Newton-Raphson Method to Obtain Multiple-objective Optimal Design

Using V-algorithm and Newton-Raphson method to obtain multiple-objective optimal design for estimating the shape of dose-response, the ED50 (the dose producing an effect midway between the expected responses at the extreme doses) and the MED (the minimum effective dose level) for the 2,3,4-parameter logistic models and for evaluating its efficiencies for the three objectives.

Version: 4.1
Depends: methods
Imports: graphics, Rcpp
LinkingTo: Rcpp
Published: 2016-02-11
Author: Seung Won Hyun, Weng Kee Wong, and Yarong Yang
Maintainer: Yarong Yang <Yarong.Yang at>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: yes
In views: ExperimentalDesign
CRAN checks: VNM results


Reference manual: VNM.pdf
Package source: VNM_4.1.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
OS X El Capitan binaries: r-release: VNM_4.1.tgz
OS X Mavericks binaries: r-oldrel: VNM_4.1.tgz
Old sources: VNM archive


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