denovolyzeR: Statistical Analyses of De Novo Genetic Variants

An integrated toolset for the analysis of de novo (sporadic) genetic sequence variants. denovolyzeR implements a mutational model that estimates the probability of a de novo genetic variant arising in each human gene, from which one can infer the expected number of de novo variants in a given population size. Observed variant frequencies can then be compared against expectation in a Poisson framework. denovolyzeR provides a suite of functions to implement these analyses for the interpretation of de novo variation in human disease.

Version: 0.2.0
Depends: R (≥ 3.1.0)
Imports: dplyr (≥ 0.3), reshape2 (≥ 1.4)
Suggests: knitr, rmarkdown
Published: 2016-08-01
Author: James Ware [aut, cre], Jason Homsy [ctb], Kaitlin Samocha [ctb]
Maintainer: James Ware <j.ware at>
License: GPL-3
NeedsCompilation: no
Citation: denovolyzeR citation info
Materials: NEWS
CRAN checks: denovolyzeR results


Reference manual: denovolyzeR.pdf
Vignettes: denovolyzeR_intro
Package source: denovolyzeR_0.2.0.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
OS X Mavericks binaries: r-release: denovolyzeR_0.2.0.tgz, r-oldrel: denovolyzeR_0.2.0.tgz
Old sources: denovolyzeR archive


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