iMRMC: Multi-Reader, Multi-Case Analysis Methods (ROC, Agreement, and
Do Multi-Reader, Multi-Case (MRMC) analyses of data from imaging studies where clinicians (readers)
evaluate patient images (cases). What does this mean? ... Many imaging studies are designed
so that every reader reads every case in all modalities, a fully-crossed study. In this case, the
data is cross-correlated, and we consider the readers and cases to be cross-correlated random effects.
An MRMC analysis accounts for the variability and correlations from the readers and cases when
estimating variances, confidence intervals, and p-values. The functions in this package can treat
arbitrary study designs and studies with missing data, not just fully-crossed study designs.
The initial package analyzes the reader-average area under the receiver operating characteristic (ROC)
curve with U-statistics according to Gallas, Bandos, Samuelson,
and Wagner 2009 <doi:10.1080/03610920802610084>.
Additional functions analyze other endpoints with U-statistics (binary performance
and score differences) following the work by Gallas, Pennello, and Myers 2007
Package development and documentation is at <https://github.com/DIDSR/iMRMC/tree/master>.
||R (≥ 3.5.0)
||Brandon Gallas <Brandon.Gallas at fda.hhs.gov>
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