mcr: Method Comparison Regression

Regression methods to quantify the relation between two measurement methods are provided by this package. In particular it addresses regression problems with errors in both variables and without repeated measurements. It implements the CLSI recommendations (see J. A. Budd et al. (2018, <>) for analytical method comparison and bias estimation using patient samples. Furthermore, algorithms for Theil-Sen and equivariant Passing-Bablok estimators are implemented, see F. Dufey (2020, <doi:10.1515/ijb-2019-0157>) and J. Raymaekers and F. Dufey (2022, <arXiv:2202:08060>). A comprehensive overview over the implemented methods and references can be found in the manual pages "mcr-package" and "mcreg".

Version: 1.3.1
Depends: R (≥ 3.0.0), parallel, robslopes
Imports: stats, graphics, grDevices, methods
Published: 2022-11-09
Author: Sergej Potapov [aut, cre], Fabian Model [aut], Andre Schuetzenmeister ORCID iD [aut], Ekaterina Manuilova [aut], Florian Dufey ORCID iD [aut], Jakob Raymaekers ORCID iD [aut], Roche [cph, fnd]
Maintainer: Sergej Potapov <sergej.potapov at>
License: GPL (≥ 3)
NeedsCompilation: yes
CRAN checks: mcr results


Reference manual: mcr.pdf


Package source: mcr_1.3.1.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): mcr_1.3.1.tgz, r-oldrel (arm64): mcr_1.3.1.tgz, r-release (x86_64): mcr_1.3.1.tgz, r-oldrel (x86_64): mcr_1.3.1.tgz
Old sources: mcr archive


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