modACDC: Association of Covariance for Detecting Differential Co-Expression

A series of functions to implement association of covariance for detecting differential co-expression (ACDC), a novel approach for detection of differential co-expression that simultaneously accommodates multiple phenotypes or exposures with binary, ordinal, or continuous data types. Users can use the default method which identifies modules by Partition or may supply their own modules. Also included are functions to choose an information loss criterion (ILC) for Partition using OmicS-data-based Complex trait Analysis (OSCA). The manuscript describing these methods is as follows: Queen K, Nguyen MN, Gilliland F, Chun S, Raby BA, Millstein J. "ACDC: a general approach for detecting phenotype or exposure associated co-expression" (2023) <>.

Version: 1.0.0
Depends: R (≥ 4.1.0)
Imports: CCA, CCP, data.table, foreach, ggplot2, partition, doParallel, parallel, utils, stats, tidyr
Published: 2023-05-10
Author: Katelyn Queen ORCID iD [aut, cre, cph], Joshua Millstein ORCID iD [aut, cph]
Maintainer: Katelyn Queen <kjqueen at>
License: MIT + file LICENSE
NeedsCompilation: no
Materials: README NEWS
CRAN checks: modACDC results


Reference manual: modACDC.pdf


Package source: modACDC_1.0.0.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): modACDC_1.0.0.tgz, r-oldrel (arm64): modACDC_1.0.0.tgz, r-release (x86_64): modACDC_1.0.0.tgz, r-oldrel (x86_64): modACDC_1.0.0.tgz


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