mrgsolve: Simulate from ODE-Based Population PK/PD and Systems Pharmacology Models

Facilitates simulation from hierarchical, ordinary differential equation (ODE) based models typically employed in drug development. A model specification file is created consisting of R and C++ code that is parsed, compiled, and dynamically loaded into the R session. Input data are passed in and simulated data are returned as R objects. A dosing event engine allows interventions (bolus and infusion) to be managed separately from the model code. Differential equations are solved with the 'DLSODA' routine in 'ODEPACK' (<https://computation.llnl.gov/casc/odepack/>).

Version: 0.8.6
Depends: R (≥ 3.1.2), methods
Imports: Rcpp (≥ 0.12.3), dplyr (≥ 0.5.0), magrittr (≥ 1.5), lazyeval (≥ 0.1.10), RcppArmadillo (≥ 0.5.600.2.0), tibble (≥ 1.2)
LinkingTo: Rcpp (≥ 0.12.1), RcppArmadillo (≥ 0.5.600.2.0), BH
Suggests: lattice, testthat, XML, rmarkdown
Published: 2017-03-16
Author: Kyle T Baron [aut, cre], Alan C Hindmarsh [ctb], Linda R Petzold [ctb], Bill Gillespie [ctb], Charles Margossian [ctb], Devin Pastoor [ctb], Metrum Research Group LLC [cph]
Maintainer: Kyle T Baron <kyleb at metrumrg.com>
BugReports: https://github.com/metrumresearchgroup/mrgsolve/issues
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
Copyright: Metrum Research Group, LLC 2017
URL: https://github.com/metrumresearchgroup/mrgsolve
NeedsCompilation: yes
In views: Pharmacokinetics
CRAN checks: mrgsolve results

Downloads:

Reference manual: mrgsolve.pdf
Package source: mrgsolve_0.8.6.tar.gz
Windows binaries: r-devel: mrgsolve_0.8.6.zip, r-release: mrgsolve_0.8.6.zip, r-oldrel: mrgsolve_0.8.6.zip
OS X El Capitan binaries: r-release: mrgsolve_0.8.6.tgz
OS X Mavericks binaries: r-oldrel: mrgsolve_0.8.6.tgz
Old sources: mrgsolve archive

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