nlmixr: Nonlinear Mixed Effects Models in Population Pharmacokinetics and Pharmacodynamics

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'RxODE' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Version: 0.9.0-3
Depends: R (≥ 3.2), nlme, RxODE
Imports: Rcpp (≥ 0.12.3), brew, lattice, parallel, lbfgs, inline, dparser, methods, ggplot2, memoise, rex, minqa, Matrix, numDeriv, R.utils, mvtnorm, n1qn1, PreciseSums
LinkingTo: RcppArmadillo (≥ 0.5.600.2.0), dparser (≥ 0.1.8), Rcpp (≥ 0.12.3), RcppEigen (≥, StanHeaders, BH
Suggests: knitr, rmarkdown, dplyr, data.table, lbfgsb3, testthat, madness, devtools, expm, matrixcalc, reshape2
Published: 2018-02-07
Author: Matthew Fidler [aut], Yuan Xiong [aut], Rik Schoemaker [aut], Justin Wilkins [aut], Mirjam Trame [aut], Teun Post [aut], Robert Leary [ctb], Wenping Wang [aut, cre], Hadley Wickham [ctb], Dirk Eddelbuettel [cph], David Ardia [cph], Katharine Mullen [cph], Sylvan Elhay [cph], Jaroslav Kautsky [cph], John Burkardt [cph], Shanjie Zhang [cph], Jianming Jin [cph]
Maintainer: Wenping Wang <wwang8198 at>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: yes
CRAN checks: nlmixr results


Reference manual: nlmixr.pdf
Vignettes: Installing nlmixr
Running PK models with nlmixr
Package source: nlmixr_0.9.0-3.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
OS X binaries: r-release: nlmixr_0.9.0-3.tgz, r-oldrel: not available
Old sources: nlmixr archive


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