GMAC: Genomic Mediation Analysis with Adaptive Confounding Adjustment

Performs genomic mediation analysis with adaptive confounding adjustment (GMAC) proposed by Yang et al. (2017) <doi:10.1101/078683>. It implements large scale mediation analysis and adaptively selects potential confounding variables to adjust for each mediation test from a pool of candidate confounders. The package is tailored for but not limited to genomic mediation analysis (e.g., cis-gene mediating trans-gene regulation pattern where an eQTL, its cis-linking gene transcript, and its trans-gene transcript play the roles as treatment, mediator and the outcome, respectively), restricting to scenarios with the presence of cis-association (i.e., treatment-mediator association) and random eQTL (i.e., treatment).

Version: 3.1
Depends: parallel
Published: 2022-03-17
DOI: 10.32614/CRAN.package.GMAC
Author: Fan Yang, Jiebiao Wang and Lin Chen
Maintainer: Jiebiao Wang < at>
License: GPL-2 | GPL-3 [expanded from: GPL]
NeedsCompilation: no
CRAN checks: GMAC results


Reference manual: GMAC.pdf


Package source: GMAC_3.1.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): GMAC_3.1.tgz, r-oldrel (arm64): GMAC_3.1.tgz, r-release (x86_64): GMAC_3.1.tgz, r-oldrel (x86_64): GMAC_3.1.tgz
Old sources: GMAC archive


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