GWsignif: Estimating Genome-Wide Significance for Whole Genome Sequencing Studies, Either Single SNP Tests or Region-Based Tests

The correlations and linkage disequilibrium between tests can vary as a function of minor allele frequency thresholds used to filter variants, and also varies with different choices of test statistic for region-based tests. Appropriate genome-wide significance thresholds can be estimated empirically through permutation on only a small proportion of the whole genome.

Version: 1.2
Published: 2016-09-12
DOI: 10.32614/CRAN.package.GWsignif
Author: ChangJiang Xu and Celia M.T. Greenwood
Maintainer: ChangJiang Xu <changjiang.h.xu at>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: no
CRAN checks: GWsignif results


Reference manual: GWsignif.pdf


Package source: GWsignif_1.2.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): GWsignif_1.2.tgz, r-oldrel (arm64): GWsignif_1.2.tgz, r-release (x86_64): GWsignif_1.2.tgz, r-oldrel (x86_64): GWsignif_1.2.tgz
Old sources: GWsignif archive


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