Methods Used for Dose-Aware Concentration Interpolation/Extrapolation

William Denney

Introduction

Interpolation and extrapolation with awareness of doses occurring before, at the same time of, or after the requested interpolation time point must account for many interactions. To ensure clarity in the interpolation/extrapolation methods and the decisions made by the algorithm, each potential choice is listed below with its accompanying calculation method. The code used to generate the table is the same as the code within the function.

Methods

The method list below is described and sorted in order of how many scenarios the method is applied to in the list.

For each of the summary tables below, the column headers are as follows:

Observed concentration

Copy the input concentration at the given time to the output.

Event Before Event At Event After
conc conc conc
conc conc conc_dose
conc conc conc_dose_iv_bolus_after
conc conc dose
conc conc dose_iv_bolus_after
conc conc none
conc conc_dose conc
conc conc_dose conc_dose
conc conc_dose conc_dose_iv_bolus_after
conc conc_dose dose
conc conc_dose dose_iv_bolus_after
conc conc_dose none
conc conc_dose_iv_bolus_after conc
conc conc_dose_iv_bolus_after conc_dose
conc conc_dose_iv_bolus_after dose
conc conc_dose_iv_bolus_after none
conc_dose conc conc
conc_dose conc conc_dose
conc_dose conc conc_dose_iv_bolus_after
conc_dose conc dose
conc_dose conc dose_iv_bolus_after
conc_dose conc none
conc_dose conc_dose conc
conc_dose conc_dose conc_dose
conc_dose conc_dose conc_dose_iv_bolus_after
conc_dose conc_dose dose
conc_dose conc_dose dose_iv_bolus_after
conc_dose conc_dose none
conc_dose conc_dose_iv_bolus_after conc
conc_dose conc_dose_iv_bolus_after conc_dose
conc_dose conc_dose_iv_bolus_after dose
conc_dose conc_dose_iv_bolus_after none
conc_dose_iv_bolus_after conc conc
conc_dose_iv_bolus_after conc conc_dose
conc_dose_iv_bolus_after conc conc_dose_iv_bolus_after
conc_dose_iv_bolus_after conc dose
conc_dose_iv_bolus_after conc dose_iv_bolus_after
conc_dose_iv_bolus_after conc none
conc_dose_iv_bolus_after conc_dose conc
conc_dose_iv_bolus_after conc_dose conc_dose
conc_dose_iv_bolus_after conc_dose conc_dose_iv_bolus_after
conc_dose_iv_bolus_after conc_dose dose
conc_dose_iv_bolus_after conc_dose dose_iv_bolus_after
conc_dose_iv_bolus_after conc_dose none
dose conc conc
dose conc conc_dose
dose conc conc_dose_iv_bolus_after
dose conc dose
dose conc dose_iv_bolus_after
dose conc none
dose conc_dose conc
dose conc_dose conc_dose
dose conc_dose conc_dose_iv_bolus_after
dose conc_dose dose
dose conc_dose dose_iv_bolus_after
dose conc_dose none
dose conc_dose_iv_bolus_after conc
dose conc_dose_iv_bolus_after conc_dose
dose conc_dose_iv_bolus_after dose
dose conc_dose_iv_bolus_after none
dose_iv_bolus_after conc conc
dose_iv_bolus_after conc conc_dose
dose_iv_bolus_after conc conc_dose_iv_bolus_after
dose_iv_bolus_after conc dose
dose_iv_bolus_after conc dose_iv_bolus_after
dose_iv_bolus_after conc none
dose_iv_bolus_after conc_dose conc
dose_iv_bolus_after conc_dose conc_dose
dose_iv_bolus_after conc_dose conc_dose_iv_bolus_after
dose_iv_bolus_after conc_dose dose
dose_iv_bolus_after conc_dose dose_iv_bolus_after
dose_iv_bolus_after conc_dose none
none conc conc
none conc conc_dose
none conc conc_dose_iv_bolus_after
none conc dose
none conc dose_iv_bolus_after
none conc none
none conc_dose conc
none conc_dose conc_dose
none conc_dose conc_dose_iv_bolus_after
none conc_dose dose
none conc_dose dose_iv_bolus_after
none conc_dose none
none conc_dose_iv_bolus_after conc
none conc_dose_iv_bolus_after conc_dose
none conc_dose_iv_bolus_after dose
none conc_dose_iv_bolus_after none

Impossible combinations

The event combination cannot exist.

Event Before Event At Event After
conc conc_dose_iv_bolus_after conc_dose_iv_bolus_after
conc conc_dose_iv_bolus_after dose_iv_bolus_after
conc dose_iv_bolus_after conc_dose_iv_bolus_after
conc dose_iv_bolus_after dose_iv_bolus_after
conc output_only conc_dose_iv_bolus_after
conc output_only dose_iv_bolus_after
conc_dose conc_dose_iv_bolus_after conc_dose_iv_bolus_after
conc_dose conc_dose_iv_bolus_after dose_iv_bolus_after
conc_dose dose_iv_bolus_after conc_dose_iv_bolus_after
conc_dose dose_iv_bolus_after dose_iv_bolus_after
conc_dose output_only conc_dose_iv_bolus_after
conc_dose output_only dose_iv_bolus_after
conc_dose_iv_bolus_after conc_dose_iv_bolus_after conc
conc_dose_iv_bolus_after conc_dose_iv_bolus_after conc_dose
conc_dose_iv_bolus_after conc_dose_iv_bolus_after conc_dose_iv_bolus_after
conc_dose_iv_bolus_after conc_dose_iv_bolus_after dose
conc_dose_iv_bolus_after conc_dose_iv_bolus_after dose_iv_bolus_after
conc_dose_iv_bolus_after conc_dose_iv_bolus_after none
conc_dose_iv_bolus_after dose_iv_bolus_after conc
conc_dose_iv_bolus_after dose_iv_bolus_after conc_dose
conc_dose_iv_bolus_after dose_iv_bolus_after conc_dose_iv_bolus_after
conc_dose_iv_bolus_after dose_iv_bolus_after dose
conc_dose_iv_bolus_after dose_iv_bolus_after dose_iv_bolus_after
conc_dose_iv_bolus_after dose_iv_bolus_after none
conc_dose_iv_bolus_after output_only conc_dose_iv_bolus_after
conc_dose_iv_bolus_after output_only dose_iv_bolus_after
dose conc_dose_iv_bolus_after conc_dose_iv_bolus_after
dose conc_dose_iv_bolus_after dose_iv_bolus_after
dose dose_iv_bolus_after conc_dose_iv_bolus_after
dose dose_iv_bolus_after dose_iv_bolus_after
dose output_only conc_dose_iv_bolus_after
dose output_only dose_iv_bolus_after
dose_iv_bolus_after conc_dose_iv_bolus_after conc
dose_iv_bolus_after conc_dose_iv_bolus_after conc_dose
dose_iv_bolus_after conc_dose_iv_bolus_after conc_dose_iv_bolus_after
dose_iv_bolus_after conc_dose_iv_bolus_after dose
dose_iv_bolus_after conc_dose_iv_bolus_after dose_iv_bolus_after
dose_iv_bolus_after conc_dose_iv_bolus_after none
dose_iv_bolus_after dose_iv_bolus_after conc
dose_iv_bolus_after dose_iv_bolus_after conc_dose
dose_iv_bolus_after dose_iv_bolus_after conc_dose_iv_bolus_after
dose_iv_bolus_after dose_iv_bolus_after dose
dose_iv_bolus_after dose_iv_bolus_after dose_iv_bolus_after
dose_iv_bolus_after dose_iv_bolus_after none
dose_iv_bolus_after output_only conc_dose_iv_bolus_after
dose_iv_bolus_after output_only dose_iv_bolus_after
none conc_dose_iv_bolus_after conc_dose_iv_bolus_after
none conc_dose_iv_bolus_after dose_iv_bolus_after
none dose_iv_bolus_after conc_dose_iv_bolus_after
none dose_iv_bolus_after dose_iv_bolus_after
none output_only conc_dose_iv_bolus_after
none output_only dose_iv_bolus_after

Doses with no concentrations between

Two doses with no concentrations between them, return NA.

Event Before Event At Event After
conc_dose dose conc
conc_dose dose conc_dose
conc_dose dose conc_dose_iv_bolus_after
conc_dose dose dose
conc_dose dose dose_iv_bolus_after
conc_dose dose none
conc_dose output_only conc_dose
conc_dose output_only dose
dose dose conc
dose dose conc_dose
dose dose conc_dose_iv_bolus_after
dose dose dose
dose dose dose_iv_bolus_after
dose dose none
dose output_only conc_dose
dose output_only dose

Extrapolation

Extrapolate from a concentration to a dose

Event Before Event At Event After
conc dose conc
conc dose conc_dose
conc dose conc_dose_iv_bolus_after
conc dose dose
conc dose dose_iv_bolus_after
conc dose none
conc output_only dose
conc output_only none
conc_dose_iv_bolus_after dose conc
conc_dose_iv_bolus_after dose conc_dose
conc_dose_iv_bolus_after dose conc_dose_iv_bolus_after
conc_dose_iv_bolus_after dose dose
conc_dose_iv_bolus_after dose dose_iv_bolus_after
conc_dose_iv_bolus_after dose none
conc_dose_iv_bolus_after output_only dose
conc_dose_iv_bolus_after output_only none

Immediately after an IV bolus without a concentration next

Cannot calculate C0 without a concentration after an IV bolus; return NA.

Event Before Event At Event After
conc dose_iv_bolus_after dose
conc dose_iv_bolus_after none
conc_dose dose_iv_bolus_after dose
conc_dose dose_iv_bolus_after none
dose dose_iv_bolus_after dose
dose dose_iv_bolus_after none
dose_iv_bolus_after dose conc
dose_iv_bolus_after dose conc_dose
dose_iv_bolus_after dose conc_dose_iv_bolus_after
dose_iv_bolus_after dose dose
dose_iv_bolus_after dose dose_iv_bolus_after
dose_iv_bolus_after dose none
none dose_iv_bolus_after dose
none dose_iv_bolus_after none

Before all events

Interpolation before any events is NA or zero (0) depending on the value of conc.origin. conc.origin defaults to zero which is the implicit assumption that a complete washout occurred and there is no endogenous source of the analyte.

Event Before Event At Event After
none dose conc
none dose conc_dose
none dose conc_dose_iv_bolus_after
none dose dose
none dose dose_iv_bolus_after
none dose none
none output_only conc
none output_only conc_dose
none output_only dose
none output_only none

Immediately after an IV bolus with a concentration next

Calculate C0 for the time immediately after an IV bolus. First, attempt using log slope back-extrapolation. If that fails, use the first concentration after the dose as C0.

Event Before Event At Event After
conc dose_iv_bolus_after conc
conc dose_iv_bolus_after conc_dose
conc_dose dose_iv_bolus_after conc
conc_dose dose_iv_bolus_after conc_dose
dose dose_iv_bolus_after conc
dose dose_iv_bolus_after conc_dose
none dose_iv_bolus_after conc
none dose_iv_bolus_after conc_dose

Interpolation

With concentrations before and after and not an IV bolus before, interpolate between observed concentrations.

Event Before Event At Event After
conc output_only conc
conc output_only conc_dose
conc_dose output_only conc
conc_dose_iv_bolus_after output_only conc
conc_dose_iv_bolus_after output_only conc_dose

After an IV bolus with a concentration next

First, calculate C0 using log slope back-extrapolation (falling back to the first post-dose concentration if that fails). Then, interpolate between C0 and the first post-dose concentration.

Event Before Event At Event After
dose_iv_bolus_after output_only conc
dose_iv_bolus_after output_only conc_dose

After an IV bolus without a concentration next

Between an IV bolus and anything other than a concentration, interpolation cannot occur. Return NA

Event Before Event At Event After
dose_iv_bolus_after output_only dose
dose_iv_bolus_after output_only none

Dose as the last event in the timeline and requesting a concentration after

Cannot estimate the concentration after a dose without concentrations after the dose, return NA.

Event Before Event At Event After
conc_dose output_only none
dose output_only none

Dose before, concentration after without a dose

If the concentration at the dose is estimable, interpolate. Otherwise, NA.

Event Before Event At Event After
dose output_only conc

Appendix: Complete Methods Table

Event Before Event At Event After Method Used
conc conc conc Observed concentration
conc conc conc_dose Observed concentration
conc conc conc_dose_iv_bolus_after Observed concentration
conc conc dose Observed concentration
conc conc dose_iv_bolus_after Observed concentration
conc conc none Observed concentration
conc conc_dose conc Observed concentration
conc conc_dose conc_dose Observed concentration
conc conc_dose conc_dose_iv_bolus_after Observed concentration
conc conc_dose dose Observed concentration
conc conc_dose dose_iv_bolus_after Observed concentration
conc conc_dose none Observed concentration
conc conc_dose_iv_bolus_after conc Observed concentration
conc conc_dose_iv_bolus_after conc_dose Observed concentration
conc conc_dose_iv_bolus_after conc_dose_iv_bolus_after Impossible combinations
conc conc_dose_iv_bolus_after dose Observed concentration
conc conc_dose_iv_bolus_after dose_iv_bolus_after Impossible combinations
conc conc_dose_iv_bolus_after none Observed concentration
conc dose conc Extrapolation
conc dose conc_dose Extrapolation
conc dose conc_dose_iv_bolus_after Extrapolation
conc dose dose Extrapolation
conc dose dose_iv_bolus_after Extrapolation
conc dose none Extrapolation
conc dose_iv_bolus_after conc Immediately after an IV bolus with a concentration next
conc dose_iv_bolus_after conc_dose Immediately after an IV bolus with a concentration next
conc dose_iv_bolus_after conc_dose_iv_bolus_after Impossible combinations
conc dose_iv_bolus_after dose Immediately after an IV bolus without a concentration next
conc dose_iv_bolus_after dose_iv_bolus_after Impossible combinations
conc dose_iv_bolus_after none Immediately after an IV bolus without a concentration next
conc output_only conc Interpolation
conc output_only conc_dose Interpolation
conc output_only conc_dose_iv_bolus_after Impossible combinations
conc output_only dose Extrapolation
conc output_only dose_iv_bolus_after Impossible combinations
conc output_only none Extrapolation
conc_dose conc conc Observed concentration
conc_dose conc conc_dose Observed concentration
conc_dose conc conc_dose_iv_bolus_after Observed concentration
conc_dose conc dose Observed concentration
conc_dose conc dose_iv_bolus_after Observed concentration
conc_dose conc none Observed concentration
conc_dose conc_dose conc Observed concentration
conc_dose conc_dose conc_dose Observed concentration
conc_dose conc_dose conc_dose_iv_bolus_after Observed concentration
conc_dose conc_dose dose Observed concentration
conc_dose conc_dose dose_iv_bolus_after Observed concentration
conc_dose conc_dose none Observed concentration
conc_dose conc_dose_iv_bolus_after conc Observed concentration
conc_dose conc_dose_iv_bolus_after conc_dose Observed concentration
conc_dose conc_dose_iv_bolus_after conc_dose_iv_bolus_after Impossible combinations
conc_dose conc_dose_iv_bolus_after dose Observed concentration
conc_dose conc_dose_iv_bolus_after dose_iv_bolus_after Impossible combinations
conc_dose conc_dose_iv_bolus_after none Observed concentration
conc_dose dose conc Doses with no concentrations between
conc_dose dose conc_dose Doses with no concentrations between
conc_dose dose conc_dose_iv_bolus_after Doses with no concentrations between
conc_dose dose dose Doses with no concentrations between
conc_dose dose dose_iv_bolus_after Doses with no concentrations between
conc_dose dose none Doses with no concentrations between
conc_dose dose_iv_bolus_after conc Immediately after an IV bolus with a concentration next
conc_dose dose_iv_bolus_after conc_dose Immediately after an IV bolus with a concentration next
conc_dose dose_iv_bolus_after conc_dose_iv_bolus_after Impossible combinations
conc_dose dose_iv_bolus_after dose Immediately after an IV bolus without a concentration next
conc_dose dose_iv_bolus_after dose_iv_bolus_after Impossible combinations
conc_dose dose_iv_bolus_after none Immediately after an IV bolus without a concentration next
conc_dose output_only conc Interpolation
conc_dose output_only conc_dose Doses with no concentrations between
conc_dose output_only conc_dose_iv_bolus_after Impossible combinations
conc_dose output_only dose Doses with no concentrations between
conc_dose output_only dose_iv_bolus_after Impossible combinations
conc_dose output_only none Dose as the last event in the timeline and requesting a concentration after
conc_dose_iv_bolus_after conc conc Observed concentration
conc_dose_iv_bolus_after conc conc_dose Observed concentration
conc_dose_iv_bolus_after conc conc_dose_iv_bolus_after Observed concentration
conc_dose_iv_bolus_after conc dose Observed concentration
conc_dose_iv_bolus_after conc dose_iv_bolus_after Observed concentration
conc_dose_iv_bolus_after conc none Observed concentration
conc_dose_iv_bolus_after conc_dose conc Observed concentration
conc_dose_iv_bolus_after conc_dose conc_dose Observed concentration
conc_dose_iv_bolus_after conc_dose conc_dose_iv_bolus_after Observed concentration
conc_dose_iv_bolus_after conc_dose dose Observed concentration
conc_dose_iv_bolus_after conc_dose dose_iv_bolus_after Observed concentration
conc_dose_iv_bolus_after conc_dose none Observed concentration
conc_dose_iv_bolus_after conc_dose_iv_bolus_after conc Impossible combinations
conc_dose_iv_bolus_after conc_dose_iv_bolus_after conc_dose Impossible combinations
conc_dose_iv_bolus_after conc_dose_iv_bolus_after conc_dose_iv_bolus_after Impossible combinations
conc_dose_iv_bolus_after conc_dose_iv_bolus_after dose Impossible combinations
conc_dose_iv_bolus_after conc_dose_iv_bolus_after dose_iv_bolus_after Impossible combinations
conc_dose_iv_bolus_after conc_dose_iv_bolus_after none Impossible combinations
conc_dose_iv_bolus_after dose conc Extrapolation
conc_dose_iv_bolus_after dose conc_dose Extrapolation
conc_dose_iv_bolus_after dose conc_dose_iv_bolus_after Extrapolation
conc_dose_iv_bolus_after dose dose Extrapolation
conc_dose_iv_bolus_after dose dose_iv_bolus_after Extrapolation
conc_dose_iv_bolus_after dose none Extrapolation
conc_dose_iv_bolus_after dose_iv_bolus_after conc Impossible combinations
conc_dose_iv_bolus_after dose_iv_bolus_after conc_dose Impossible combinations
conc_dose_iv_bolus_after dose_iv_bolus_after conc_dose_iv_bolus_after Impossible combinations
conc_dose_iv_bolus_after dose_iv_bolus_after dose Impossible combinations
conc_dose_iv_bolus_after dose_iv_bolus_after dose_iv_bolus_after Impossible combinations
conc_dose_iv_bolus_after dose_iv_bolus_after none Impossible combinations
conc_dose_iv_bolus_after output_only conc Interpolation
conc_dose_iv_bolus_after output_only conc_dose Interpolation
conc_dose_iv_bolus_after output_only conc_dose_iv_bolus_after Impossible combinations
conc_dose_iv_bolus_after output_only dose Extrapolation
conc_dose_iv_bolus_after output_only dose_iv_bolus_after Impossible combinations
conc_dose_iv_bolus_after output_only none Extrapolation
dose conc conc Observed concentration
dose conc conc_dose Observed concentration
dose conc conc_dose_iv_bolus_after Observed concentration
dose conc dose Observed concentration
dose conc dose_iv_bolus_after Observed concentration
dose conc none Observed concentration
dose conc_dose conc Observed concentration
dose conc_dose conc_dose Observed concentration
dose conc_dose conc_dose_iv_bolus_after Observed concentration
dose conc_dose dose Observed concentration
dose conc_dose dose_iv_bolus_after Observed concentration
dose conc_dose none Observed concentration
dose conc_dose_iv_bolus_after conc Observed concentration
dose conc_dose_iv_bolus_after conc_dose Observed concentration
dose conc_dose_iv_bolus_after conc_dose_iv_bolus_after Impossible combinations
dose conc_dose_iv_bolus_after dose Observed concentration
dose conc_dose_iv_bolus_after dose_iv_bolus_after Impossible combinations
dose conc_dose_iv_bolus_after none Observed concentration
dose dose conc Doses with no concentrations between
dose dose conc_dose Doses with no concentrations between
dose dose conc_dose_iv_bolus_after Doses with no concentrations between
dose dose dose Doses with no concentrations between
dose dose dose_iv_bolus_after Doses with no concentrations between
dose dose none Doses with no concentrations between
dose dose_iv_bolus_after conc Immediately after an IV bolus with a concentration next
dose dose_iv_bolus_after conc_dose Immediately after an IV bolus with a concentration next
dose dose_iv_bolus_after conc_dose_iv_bolus_after Impossible combinations
dose dose_iv_bolus_after dose Immediately after an IV bolus without a concentration next
dose dose_iv_bolus_after dose_iv_bolus_after Impossible combinations
dose dose_iv_bolus_after none Immediately after an IV bolus without a concentration next
dose output_only conc Dose before, concentration after without a dose
dose output_only conc_dose Doses with no concentrations between
dose output_only conc_dose_iv_bolus_after Impossible combinations
dose output_only dose Doses with no concentrations between
dose output_only dose_iv_bolus_after Impossible combinations
dose output_only none Dose as the last event in the timeline and requesting a concentration after
dose_iv_bolus_after conc conc Observed concentration
dose_iv_bolus_after conc conc_dose Observed concentration
dose_iv_bolus_after conc conc_dose_iv_bolus_after Observed concentration
dose_iv_bolus_after conc dose Observed concentration
dose_iv_bolus_after conc dose_iv_bolus_after Observed concentration
dose_iv_bolus_after conc none Observed concentration
dose_iv_bolus_after conc_dose conc Observed concentration
dose_iv_bolus_after conc_dose conc_dose Observed concentration
dose_iv_bolus_after conc_dose conc_dose_iv_bolus_after Observed concentration
dose_iv_bolus_after conc_dose dose Observed concentration
dose_iv_bolus_after conc_dose dose_iv_bolus_after Observed concentration
dose_iv_bolus_after conc_dose none Observed concentration
dose_iv_bolus_after conc_dose_iv_bolus_after conc Impossible combinations
dose_iv_bolus_after conc_dose_iv_bolus_after conc_dose Impossible combinations
dose_iv_bolus_after conc_dose_iv_bolus_after conc_dose_iv_bolus_after Impossible combinations
dose_iv_bolus_after conc_dose_iv_bolus_after dose Impossible combinations
dose_iv_bolus_after conc_dose_iv_bolus_after dose_iv_bolus_after Impossible combinations
dose_iv_bolus_after conc_dose_iv_bolus_after none Impossible combinations
dose_iv_bolus_after dose conc Immediately after an IV bolus without a concentration next
dose_iv_bolus_after dose conc_dose Immediately after an IV bolus without a concentration next
dose_iv_bolus_after dose conc_dose_iv_bolus_after Immediately after an IV bolus without a concentration next
dose_iv_bolus_after dose dose Immediately after an IV bolus without a concentration next
dose_iv_bolus_after dose dose_iv_bolus_after Immediately after an IV bolus without a concentration next
dose_iv_bolus_after dose none Immediately after an IV bolus without a concentration next
dose_iv_bolus_after dose_iv_bolus_after conc Impossible combinations
dose_iv_bolus_after dose_iv_bolus_after conc_dose Impossible combinations
dose_iv_bolus_after dose_iv_bolus_after conc_dose_iv_bolus_after Impossible combinations
dose_iv_bolus_after dose_iv_bolus_after dose Impossible combinations
dose_iv_bolus_after dose_iv_bolus_after dose_iv_bolus_after Impossible combinations
dose_iv_bolus_after dose_iv_bolus_after none Impossible combinations
dose_iv_bolus_after output_only conc After an IV bolus with a concentration next
dose_iv_bolus_after output_only conc_dose After an IV bolus with a concentration next
dose_iv_bolus_after output_only conc_dose_iv_bolus_after Impossible combinations
dose_iv_bolus_after output_only dose After an IV bolus without a concentration next
dose_iv_bolus_after output_only dose_iv_bolus_after Impossible combinations
dose_iv_bolus_after output_only none After an IV bolus without a concentration next
none conc conc Observed concentration
none conc conc_dose Observed concentration
none conc conc_dose_iv_bolus_after Observed concentration
none conc dose Observed concentration
none conc dose_iv_bolus_after Observed concentration
none conc none Observed concentration
none conc_dose conc Observed concentration
none conc_dose conc_dose Observed concentration
none conc_dose conc_dose_iv_bolus_after Observed concentration
none conc_dose dose Observed concentration
none conc_dose dose_iv_bolus_after Observed concentration
none conc_dose none Observed concentration
none conc_dose_iv_bolus_after conc Observed concentration
none conc_dose_iv_bolus_after conc_dose Observed concentration
none conc_dose_iv_bolus_after conc_dose_iv_bolus_after Impossible combinations
none conc_dose_iv_bolus_after dose Observed concentration
none conc_dose_iv_bolus_after dose_iv_bolus_after Impossible combinations
none conc_dose_iv_bolus_after none Observed concentration
none dose conc Before all events
none dose conc_dose Before all events
none dose conc_dose_iv_bolus_after Before all events
none dose dose Before all events
none dose dose_iv_bolus_after Before all events
none dose none Before all events
none dose_iv_bolus_after conc Immediately after an IV bolus with a concentration next
none dose_iv_bolus_after conc_dose Immediately after an IV bolus with a concentration next
none dose_iv_bolus_after conc_dose_iv_bolus_after Impossible combinations
none dose_iv_bolus_after dose Immediately after an IV bolus without a concentration next
none dose_iv_bolus_after dose_iv_bolus_after Impossible combinations
none dose_iv_bolus_after none Immediately after an IV bolus without a concentration next
none output_only conc Before all events
none output_only conc_dose Before all events
none output_only conc_dose_iv_bolus_after Impossible combinations
none output_only dose Before all events
none output_only dose_iv_bolus_after Impossible combinations
none output_only none Before all events