RARfreq: Response Adaptive Randomization with 'Frequentist' Approach

Provides functions and command-line user interface to generate allocation sequence by response-adaptive randomization for clinical trials. The package currently supports two response-adaptive randomization procedures, Doubly Adaptive Biased Coin Design ('DBCD') and Sequential Estimation-adjusted Urn Model ('SEU'), for two endpoints, binary and normal. One-sided proportion (or mean) difference and Chi-square (or 'ANOVA') hypothesis testing methods are also available in the package to facilitate the inference for treatment effect under different sample sizes and the inference for sample size under different treatment effects. Additionally, the package provides comprehensive and efficient tools to allow one to evaluate and compare the performance of randomization procedures and tests based on various criteria. Five allocation functions for 'DBCD' and six addition rule functions for 'SEU' are implemented to target allocations such as 'Neyman', 'Rosenberger' and 'Urn' allocations.

Version: 0.1.3
Imports: dplyr, ggplot2, latex2exp, magrittr, patchwork, stats, tidyr, data.table, reshape2
Suggests: spelling, testthat (≥ 3.0.0)
Published: 2023-03-02
Author: Mengjia Yu [aut], Xiu Huang [aut, cre], Hongjian Zhu [aut]
Maintainer: Xiu Huang <xiu.huang at abbvie.com>
License: MIT + file LICENSE
NeedsCompilation: no
Language: en-US
Materials: README
CRAN checks: RARfreq results


Reference manual: RARfreq.pdf


Package source: RARfreq_0.1.3.tar.gz
Windows binaries: r-devel: RARfreq_0.1.3.zip, r-release: RARfreq_0.1.3.zip, r-oldrel: RARfreq_0.1.3.zip
macOS binaries: r-release (arm64): RARfreq_0.1.3.tgz, r-oldrel (arm64): RARfreq_0.1.3.tgz, r-release (x86_64): RARfreq_0.1.3.tgz, r-oldrel (x86_64): RARfreq_0.1.3.tgz


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