YPInterimTesting: Interim Monitoring Using Adaptively Weighted Log-Rank Test in Clinical Trials

For any spending function specified by the user, this package provides corresponding boundaries for interim testing using the adaptively weighted log-rank test developed by Yang and Prentice (2010 <doi:10.1111/j.1541-0420.2009.01243.x>). The package uses a re-sampling method to obtain stopping boundaries at the interim looks.The output consists of stopping boundaries and observed values of the test statistics at the interim looks, along with nominal p-values defined as the probability of the test exceeding the specific observed test statistic value or critical value, regardless of the test behavior at other looks. The asymptotic validity of the stopping boundaries is established in Yang (2018 <doi:10.1002/sim.7958>).

Version: 1.0.3
Imports: Rcpp, MASS
LinkingTo: Rcpp
Published: 2019-06-07
Author: Daewoo Pak and Song Yang
Maintainer: Daewoo Pak <heavyrain.pak at gmail.com>
License: GPL (≥ 3)
NeedsCompilation: yes
Materials: README NEWS
CRAN checks: YPInterimTesting results

Downloads:

Reference manual: YPInterimTesting.pdf
Package source: YPInterimTesting_1.0.3.tar.gz
Windows binaries: r-devel: YPInterimTesting_1.0.3.zip, r-release: YPInterimTesting_1.0.3.zip, r-oldrel: YPInterimTesting_1.0.3.zip
OS X binaries: r-release: YPInterimTesting_1.0.3.tgz, r-oldrel: YPInterimTesting_1.0.3.tgz
Old sources: YPInterimTesting archive

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