Decorrelates a set of summary statistics (i.e., Z-scores or P-values per SNP) via Decorrelation by Orthogonal Transformation (DOT) approach and performs gene-set analyses by combining transformed statistic values; operations are performed with algorithms that rely only on the association summary results and the linkage disequilibrium (LD). For more details on DOT and its power, see Olga (2020) <doi:10.1371/journal.pcbi.1007819>.
Version: | 0.1.0 |
Depends: | R (≥ 3.5.0), mvtnorm |
Published: | 2020-11-16 |
DOI: | 10.32614/CRAN.package.dotgen |
Author: | Olga Vsevolozhskaya [aut], Dmitri Zaykin [aut], Xiaoran Tong [aut, cre] |
Maintainer: | Xiaoran Tong <tongxia1 at msu.edu> |
License: | GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
URL: | https://github.com/xiaoran831213/dotgen |
NeedsCompilation: | no |
CRAN checks: | dotgen results [issues need fixing before 2024-10-31] |
Reference manual: | dotgen.pdf |
Package source: | dotgen_0.1.0.tar.gz |
Windows binaries: | r-devel: dotgen_0.1.0.zip, r-release: dotgen_0.1.0.zip, r-oldrel: dotgen_0.1.0.zip |
macOS binaries: | r-release (arm64): dotgen_0.1.0.tgz, r-oldrel (arm64): dotgen_0.1.0.tgz, r-release (x86_64): dotgen_0.1.0.tgz, r-oldrel (x86_64): dotgen_0.1.0.tgz |
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