httk: High-Throughput Toxicokinetics

Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in vitro studies. Both physiologically-based ("PBTK") and empirical (e.g., one compartment) "TK" models can be parameterized for several hundred chemicals and multiple species. These models are solved efficiently, often using compiled (C-based) code. A Monte Carlo sampler is included for simulating biological variability and measurement limitations. Functions are also provided for exporting "PBTK" models to "SBML" and "JARNAC" for use with other simulation software. These functions and data provide a set of tools for in vitro-in vivo extrapolation ("IVIVE") of high throughput screening data (e.g., ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK").

Version: 1.5
Depends: R (≥ 2.10)
Imports: deSolve, msm, data.table, survey, mvtnorm, truncnorm, EnvStats, MASS, RColorBrewer, TeachingDemos, classInt, ks, reshape2
Suggests: ggplot2, knitr, rmarkdown, R.rsp, GGally, gplots, scales
Published: 2017-03-03
Author: John Wambaugh and Robert Pearce, Schmitt method implementation by Jimena Davis, dynamic model adapted from code by R. Woodrow Setzer, Rabbit parameters from Nisha Sipes
Maintainer: John Wambaugh <wambaugh.john at>
License: GPL-3
NeedsCompilation: yes
Materials: NEWS
CRAN checks: httk results


Reference manual: httk.pdf
Vignettes: Age distributions
Global sensitivity analysis
Global sensitivity analysis plotting
Height and weight spline fits and residuals
Hematocrit spline fits and residuals
Plotting Css95
Serum creatinine spline fits and residuals
Generating subpopulations
Evaluating HTTK models for subpopulations
Generating Figure 2
Generating Figure 3
Plotting Howgate/Johnson data
AER plotting
Virtual study populations
httk: R Package for High-Throughput Toxicokinetics
Package source: httk_1.5.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
OS X El Capitan binaries: r-release: httk_1.5.tgz
OS X Mavericks binaries: r-oldrel: httk_1.5.tgz
Old sources: httk archive


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