phase1RMD: Repeated Measurement Design for Phase I Clinical Trial

Implements our Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints from multiple treatment cycles. The package also provides a novel design to account for both multidimensional toxicity endpoints and early-stage efficacy endpoints in the phase I design. For both designs, functions are provided to recommend the next dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.

Version: 1.0.9
Depends: R (≥ 3.0.0), coda, boot, rjags, mvtnorm, ggplot2
Imports: arrayhelpers
Suggests: BiocParallel
Published: 2020-03-11
DOI: 10.32614/CRAN.package.phase1RMD
Author: Jun Yin, Yu Du, Sumithra Mandrekar
Maintainer: Jun Yin <vivien.jyin at>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: no
CRAN checks: phase1RMD results


Reference manual: phase1RMD.pdf


Package source: phase1RMD_1.0.9.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): phase1RMD_1.0.9.tgz, r-oldrel (arm64): phase1RMD_1.0.9.tgz, r-release (x86_64): phase1RMD_1.0.9.tgz, r-oldrel (x86_64): phase1RMD_1.0.9.tgz
Old sources: phase1RMD archive


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