wnl: Minimization Tool for Pharmacokinetic-Pharmacodynamic Data Analysis

This is a set of minimization tools (maximum likelihood estimation and least square fitting) to solve examples in the Johan Gabrielsson and Dan Weiner's book "Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications" 5th ed. (ISBN:9198299107). Examples include linear and nonlinear compartmental model, turn-over model, single or multiple dosing bolus/infusion/oral models, allometry, toxicokinetics, reversible metabolism, in-vitro/in-vivo extrapolation, enterohepatic circulation, metabolite modeling, Emax model, inhibitory model, tolerance model, oscillating response model, enantiomer interaction model, effect compartment model, drug-drug interaction model, receptor occupancy model, and rebound phenomena model.

Version: 0.8.1
Depends: R (≥ 3.5.0), numDeriv
Published: 2024-06-01
DOI: 10.32614/CRAN.package.wnl
Author: Kyun-Seop Bae [aut]
Maintainer: Kyun-Seop Bae <k at acr.kr>
License: GPL-3
Copyright: 2017-, Kyun-Seop Bae
URL: https://cran.r-project.org/package=wnl
NeedsCompilation: no
Materials: NEWS
In views: Pharmacokinetics
CRAN checks: wnl results


Reference manual: wnl.pdf


Package source: wnl_0.8.1.tar.gz
Windows binaries: r-devel: wnl_0.8.1.zip, r-release: wnl_0.8.1.zip, r-oldrel: wnl_0.8.1.zip
macOS binaries: r-release (arm64): wnl_0.8.1.tgz, r-oldrel (arm64): wnl_0.8.1.tgz, r-release (x86_64): wnl_0.8.1.tgz, r-oldrel (x86_64): wnl_0.8.1.tgz
Old sources: wnl archive


Please use the canonical form https://CRAN.R-project.org/package=wnl to link to this page.